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Transfer your prescription for SUMATRIPTAN 100 MG TAB on Amazon Pharmacy. FREE SHIPPING for Prime members. Curious, can you buy Imitrex over the counter? In the United States, sumatriptan (Imitrex) is a prescription-only medication. Learn why a prescription is required, how to get one, and explore safe over-the-counter alternatives. About generic Imitrex Sumatriptan (Imitrex) is an inexpensive drug used to treat migraines. It is more popular than comparable drugs. It is available in generic and brand versions. Generic sumatriptan is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. While Imitrex is a commonly prescribed medication for the treatment of migraines, it's important to explore other options that may be more cost-effective or accessible. One alternative to Generic for Imitrex is to try over-the-counter pain relievers. Learn about cost and Imitrex, financial and insurance assistance, ways to lower long-term costs, and more. 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